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1.
Rev. Assoc. Med. Bras. (1992) ; 64(5): 469-473, May 2018. tab, graf
Article in English | LILACS | ID: biblio-956476

ABSTRACT

SUMMARY BACKGROUND Some researchers have suggested that HIV infections can increase the cytokines, which might interfere with the bone metabolism and increase the risk of bone mass loss. However, this issue has yet to be consolidated in postmenopausal women. OBJECTIVE To analyze studies that evaluated the loss of bone mass through DEXA in women living with HIV. MATERIALS AND METHODS: A systematic review was conducted following the PRISMA guideline. The MEDLINE, EMBASE and Cochrane databases were consulted from January 1987 to March 2017. Studies assessing bone mineral density (BMD) in postmenopausal women living with HIV were included. The secondary outcome was to evaluate the impact of antiretroviral on BMD. RESULTS Sixty percent of the manuscripts suggested that women living with HIV had more bone loss than women in the control group, mainly in the lumbar spine. Forty percent did not observe any difference between groups. One study reported the influence of antiretroviral drugs on bone mass but did not find any difference between groups. CONCLUSION Our data suggest that HIV infections may have a negative influence on bone mass loss in women. Further studies on the mechanism of this HIV consequence are necessary to clarify the connection as well as the impact of the antiretroviral action on BMD in postmenopausal women.


Subject(s)
Humans , Female , Bone Density , HIV Infections/complications , Osteoporosis, Postmenopausal/complications , Postmenopause , HIV Infections/metabolism , HIV Infections/drug therapy , Randomized Controlled Trials as Topic , Anti-HIV Agents/therapeutic use
2.
RBM rev. bras. med ; 68(10)out. 2011.
Article in Portuguese | LILACS | ID: lil-606274

ABSTRACT

Objetivo: Analisar os aspectos relevantes do tratamento hormonal no climatério, orientado por monitorização adequada, para aumentar benefícios e reduzir riscos.Material e métodos: Análise de trabalhos e livros relevantes pertinentes ao tema, que em conjunto favoreçam a monitorização clínica, laboratorial e a individualização das mulheres climatéricas, conduzindo assim para a melhor opção de tratamento hormonal.Resultados e conclusões: As evidências da literatura e os dados observados em publicação do Setor de Ginecologia Endócrina e Climatério da Clínica Ginecológica da FMUSP mostram que a individualização das mulheres climatéricas, de acordo com suas condições clínicas, possibilita tratamento hormonal individualizado para cada mulher, oferecendo maiores benefícios e segurança.

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